ALSS (AMYOTROPHIC LATERAL SCLEROSIS)
\ˌe͡ɪˌɛlˈɛs ˌamɪətɹˈɒfɪk lˈatəɹə͡l skləɹˈə͡ʊsɪs], \ˌeɪˌɛlˈɛs ˌamɪətɹˈɒfɪk lˈatəɹəl skləɹˈəʊsɪs], \ˌeɪ_ˌɛ_l_ˈɛ_s__ ˌa_m_ɪ__ə_t_ɹ_ˈɒ_f_ɪ_k l_ˈa_t_ə_ɹ_əl s_k_l_ə_ɹ_ˈəʊ_s_ɪ_s]\
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A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
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Nearby Words
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