AMYLOID BETA PROTEIN PRECURSOR
\ˈamɪlˌɔ͡ɪd bˈiːtə pɹˈə͡ʊtiːn pɹɪkˈɜːsə], \ˈamɪlˌɔɪd bˈiːtə pɹˈəʊtiːn pɹɪkˈɜːsə], \ˈa_m_ɪ_l_ˌɔɪ_d b_ˈiː_t_ə p_ɹ_ˈəʊ_t_iː_n p_ɹ_ɪ_k_ˈɜː_s_ə]\
Sort: Oldest first
-
A precursor to the AMYLOID-BETA PROTEIN (beta/A4). Alterations in the expression of the amyloid beta-protein precursor (ABPP) gene, located on chromosome 21, plays a role in the development of the neuropathology common to both ALZHEIMER DISEASE and DOWN SYNDROME. ABPP is associated with the extensive extracellular matrix secreted by neuronal cells. Upon cleavage, this precursor produces three proteins of varying amino acid lengths: 695, 751, and 770. The beta/A4 (695 amino acids) or beta-amyloid protein is the principal component of the extracellular amyloid in senile plaques found in ALZHEIMER DISEASE; DOWN SYNDROME and, to a limited extent, in normal aging.
By DataStellar Co., Ltd
Word of the day
basidiomycota
- comprises fungi bearing the spores on basidium: Gasteromycetes (puffballs); Tiliomycetes (comprising orders Ustilaginales (smuts) and Uredinales (rusts)); Hymenomycetes (mushrooms; toadstools; agarics; bracket fungi); in some classification systems considered a division of kingdom comprises fungi bearing spores on a basidium; includes Gasteromycetes (puffballs) Tiliomycetes comprising the orders Ustilaginales (smuts) and Uredinales (rusts) Hymenomycetes (mushrooms, toadstools, agarics bracket fungi).