GRANULAR CAST
\ɡɹˈanjʊlə kˈast], \ɡɹˈanjʊlə kˈast], \ɡ_ɹ_ˈa_n_j_ʊ_l_ə k_ˈa_s_t]\
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A renal c. having a granular appearance, generally from granular degeneration of epithelium, blood, etc
By Smith Ely Jelliffe
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.