LETHAL CONCENTRATION 50 (LC50)

\lˈiːθə͡l kˌɒnsəntɹˈe͡ɪʃən fˈɪfti ˌɛlsˈiː fˈɪfti], \lˈiːθə‍l kˌɒnsəntɹˈe‍ɪʃən fˈɪfti ˌɛlsˈiː fˈɪfti], \l_ˈiː_θ_əl k_ˌɒ_n_s_ə_n_t_ɹ_ˈeɪ_ʃ_ə_n f_ˈɪ_f_t_i__ ˌɛ_l_s_ˈiː f_ˈɪ_f_t_i]\

Definitions of LETHAL CONCENTRATION 50 (LC50)

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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