PAIN INSENSITIVITY WITH ANHIDROSIS, CONGENITAL
\pˈe͡ɪn ɪnsˌɛnsɪtˈɪvɪti wɪð ˌanhɪdɹˈə͡ʊsɪs], \pˈeɪn ɪnsˌɛnsɪtˈɪvɪti wɪð ˌanhɪdɹˈəʊsɪs], \p_ˈeɪ_n ɪ_n_s_ˌɛ_n_s_ɪ_t_ˈɪ_v_ɪ_t_i w_ɪ_ð ˌa_n_h_ɪ_d_ɹ_ˈəʊ_s_ɪ_s]\
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A group of inherited disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and clinically by loss of sensation and autonomic dysfunction. There are five subtypes. Type I features autosomal dominant inheritance and distal sensory involvement. Type II is characterized by autosomal inheritance and distal and proximal sensory loss. Type III is DYSAUTONOMIA, FAMILIAL. Type IV features insensitivity to pain, heat intolerance, and mental deficiency. Type V is characterized by a selective loss of pain with intact light touch and vibratory sensation. (From Joynt, Clinical Neurology, 1995, Ch51, pp142-4)
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