TUBERCULOSIS MENINGITIDES
\tjˌuːbəkjʊlˈə͡ʊsɪs mˈɛnɪnd͡ʒˌɪta͡ɪdz], \tjˌuːbəkjʊlˈəʊsɪs mˈɛnɪndʒˌɪtaɪdz], \t_j_ˌuː_b_ə_k_j_ʊ_l_ˈəʊ_s_ɪ_s m_ˈɛ_n_ɪ_n_dʒ_ˌɪ_t_aɪ_d_z]\
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A form of bacterial meningitis caused by MYCOBACTERIUM TUBERCULOSIS or rarely MYCOBACTERIUM BOVIS. The organism seeds the meninges and forms microtuberculomas which subsequently rupture. The clinical course tends to be subacute, with progressions occurring over a period of several days or longer. Headache and meningeal irritation may be followed by SEIZURES, cranial neuropathies, focal neurologic deficits, somnolence, and eventually COMA. The illness may occur in immunocompetent individuals or as an OPPORTUNISTIC INFECTION in the ACQUIRED IMMUNODEFICIENCY SYNDROME and other immunodeficiency syndromes. (From Adams et al., Principles of Neurology, 6th ed, pp717-9)
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Word of the day
Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.