ZINC FINGER MOTIFS
\zˈɪŋk fˈɪŋɡə mə͡ʊtˈiːfs], \zˈɪŋk fˈɪŋɡə məʊtˈiːfs], \z_ˈɪ_ŋ_k f_ˈɪ_ŋ_ɡ_ə m_əʊ_t_ˈiː_f_s]\
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Motifs in DNA- and RNA-binding proteins whose amino acids are folded into a single structural unit around a zinc atom. In the classic zinc finger, one zinc atom is bound to two cysteines and two histidines. In between the cysteines and histidines are 12 residues which form a DNA binding fingertip. By variations in the composition of the sequences in the fingertip and the number and spacing of tandem repeats of the motif, zinc fingers can form a large number of different sequence specific binding sites.
By DataStellar Co., Ltd
Word of the day
Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.