CYTOTOXIC CEREBRAL EDEMA
\sˌa͡ɪtətˈɒksɪk səɹˈiːbɹə͡l ˈɛdɪmə], \sˌaɪtətˈɒksɪk səɹˈiːbɹəl ˈɛdɪmə], \s_ˌaɪ_t_ə_t_ˈɒ_k_s_ɪ_k s_ə_ɹ_ˈiː_b_ɹ_əl ˈɛ_d_ɪ_m_ə]\
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Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8 (6):301-6)
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Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.