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an accumulation of dark pigment in cartilage and other connective tissue; usually a symptom of alkaptonuria or phenol poisoning

A disease in which the metabolic products of phenylalanine and tyrosine accumulate, resulting in the deposition of HOMOGENTISIC ACID (a brown-black pigment) in the connective tissue. It occurs in ALKAPTONURIA, but has also been observed in connection with exposure to certain chemicals (e.g., phenol, trinitrophenol, benzene derivatives).

[Greek] A peculiar brownish or blackish pigmentation sometimes affecting cartilage, tendons, and capsular ligaments.

A disease marked by yellowness.

A dark colored diffuse pigmentation resembling melanin, which affects the ear cartilages, the tendons, the periosteum, the intima of the arteries, the epithelium, and sometimes the intercellular substance. [Gr.]