EATON LAMBERT MYASTHENIC SYNDROME
\ˈiːtən lˈambət mˌa͡ɪɐsθˈɛnɪk sˈɪndɹə͡ʊm], \ˈiːtən lˈambət mˌaɪɐsθˈɛnɪk sˈɪndɹəʊm], \ˈiː_t_ə_n l_ˈa_m_b_ə_t m_ˌaɪ__ɐ_s_θ_ˈɛ_n_ɪ_k s_ˈɪ_n_d_ɹ_əʊ_m]\
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An autoimmune disease characterized by weakness and fatigability of proximal muscles, particularly of the pelvic girdle, lower extremities, trunk, and shoulder girdle. There is relative sparing of extraocular and bulbar muscles. CARCINOMA, SMALL CELL of the lung is a frequently associated condition, although other malignancies and autoimmune diseases may be associated. Muscular weakness results from impaired impulse transmission at the NEUROMUSCULAR JUNCTION. Presynaptic calcium channel dysfunction leads to a reduced amount of acetylcholine being released in response to stimulation of the nerve. (From Adams et al., Principles of Neurology, 6th ed, pp 1471)
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