HEREDITARY AUTOSOMAL DOMINANT SPASTIC PARAPLEGIA
\hɪɹˈɛdɪtəɹi ˌɔːtə͡ʊsˈə͡ʊmə͡l dˈɒmɪnənt spˈastɪk pˌaɹəplˈiːd͡ʒə], \hɪɹˈɛdɪtəɹi ˌɔːtəʊsˈəʊməl dˈɒmɪnənt spˈastɪk pˌaɹəplˈiːdʒə], \h_ɪ_ɹ_ˈɛ_d_ɪ_t_ə_ɹ_i_ ˌɔː_t_əʊ_s_ˈəʊ_m_əl d_ˈɒ_m_ɪ_n_ə_n_t s_p_ˈa_s_t_ɪ_k p_ˌa_ɹ_ə_p_l_ˈiː_dʒ_ə]\
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A group of inherited diseases that share similar phenotypes but are genetically diverse. Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. Clinically, patients present with slowly progessive distal limb weakness and lower extremity spasticity. Peripheral sensory neurons may be affected in the later stages of the disease. (J Neurol Neurosurg Psychiatry 1998 Jan;64 (1):61-6; Curr Opin Neurol 1997 Aug;10 (4):313-8)
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Nearby Words
- hereditary
- hereditary amyloidoses
- hereditary amyloidosis
- hereditary ataxia
- hereditary ataxias
- Hereditary Autosomal Dominant Spastic Paraplegia
- hereditary autosomal recessive spastic paraplegia
- hereditary blood coagulation disorders
- hereditary central nervous system demyelinating diseases
- hereditary cerebellar ataxia
- hereditary cerebral amyloid angiopathy