PRESENILE DEMENTIAS
\pɹɪsˈɛna͡ɪl dɪmˈɛnʃəz], \pɹɪsˈɛnaɪl dɪmˈɛnʃəz], \p_ɹ_ɪ_s_ˈɛ_n_aɪ_l d_ɪ_m_ˈɛ_n_ʃ_ə_z]\
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A degenerative disease of the brain characterized by the insidious onset of dementia. Impairment of memory, judgement, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
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Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.