VON ECONOMO ENCEPHALITIS TYPE PARKINSONISM
\vˈɒn ɪkˈɒnəmˌə͡ʊ ɛnsˌɛfɐlˈa͡ɪtɪs tˈa͡ɪp pɑːkˈɪnsənˌɪzəm], \vˈɒn ɪkˈɒnəmˌəʊ ɛnsˌɛfɐlˈaɪtɪs tˈaɪp pɑːkˈɪnsənˌɪzəm], \v_ˈɒ_n ɪ_k_ˈɒ_n_ə_m_ˌəʊ ɛ_n_s_ˌɛ_f_ɐ_l_ˈaɪ_t_ɪ_s t_ˈaɪ_p p_ɑː_k_ˈɪ_n_s_ə_n_ˌɪ_z_ə_m]\
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Parkinsonism following encephalitis, historically seen as a sequella of encephalitis lethargica (Von Economo Encephalitis). The early age of onset, the rapid progression of symptoms followed by stabilization, and the presence of a variety of other neurological disorders (e.g., sociopathic behavior; TICS, MUSCLE SPASMS; oculogyric crises; hyperphagia; and bizarre movements) distinguish this condition from primary PARKINSON DISEASE. Pathologic features include neuronal loss and gliosis concentrated in the MESENCEPHALON; SUBTHALAMUS; and HYPOTHALAMUS. (From Adams et al., Principles of Neurology, 6th ed, p754)
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Word of the day
Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.
Nearby Words
- von
- von baer's law
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