ABNORMAL FIBRINOGENS
\ɐbnˈɔːmə͡l fˈɪbɹɪnəd͡ʒənz], \ɐbnˈɔːməl fˈɪbɹɪnədʒənz], \ɐ_b_n_ˈɔː_m_əl f_ˈɪ_b_ɹ_ɪ_n_ə_dʒ_ə_n_z]\
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Fibrinogens which have a functional defect as the result of one or more amino acid substitutions in the amino acid sequence of normal fibrinogen. Abnormalities of the fibrinogen molecule may impair any of the major steps involved in the conversion of fibrinogen into stabilized fibrin, such as cleavage of the fibrinopeptides by thrombin, polymerization and cross-linking of fibrin. The resulting dysfibrinogenemias can be clinically silent or can be associated with bleeding, thrombosis or defective wound healing.
By DataStellar Co., Ltd
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