GAG GENE PRODUCTS
\ɡˈaɡ d͡ʒˈiːn pɹˈɒdʌkts], \ɡˈaɡ dʒˈiːn pɹˈɒdʌkts], \ɡ_ˈa_ɡ dʒ_ˈiː_n p_ɹ_ˈɒ_d_ʌ_k_t_s]\
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Proteins coded by the retroviral gag gene. The products are usually synthesized as protein precursors or POLYPROTEINS, which are then cleaved by viral proteases to yield the final products. Many of the final products are associated with the nucleoprotein core of the virion. gag is short for group-specific antigen.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.