VAN BOGAERTS LEUKOENCEPHALITIS
\vˈan bˈɒɡe͡əts lˌuːkə͡ʊnsˌɛfɐlˈa͡ɪtɪs], \vˈan bˈɒɡeəts lˌuːkəʊnsˌɛfɐlˈaɪtɪs], \v_ˈa_n b_ˈɒ_ɡ_eə_t_s l_ˌuː_k_əʊ_n_s_ˌɛ_f_ɐ_l_ˈaɪ_t_ɪ_s]\
Sort: Oldest first
-
A rare, slowly progressive encephalitis caused by chronic infection with the MEASLES VIRUS. The condition occurs primarily in children and young adults, approximately 2-8 years after the initial infection. A gradual decline in intellectual abilities and behavioral alterations are followed by progressive MYOCLONUS; MUSCLE SPASTICITY; SEIZURES; DEMENTIA; autonomic dysfunction; and ATAXIA. DEATH usually occurs 1-3 years after disease onset. Pathologic features include perivascular cuffing, eosinophilic cytoplasmic inclusions, neurophagia, and fibrous gliosis. It is caused by the SSPE virus, which is a defective variant of MEASLES VIRUS. (From Adams et al., Principles of Neurology, 6th ed, pp767-8)
By DataStellar Co., Ltd
Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.